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Airborne Fungal Diseases
Fungal Infection
Immune Compromised Hosts
Cryptococcus
Candida
Skin Infection with Fungi
Fungal Contamination of Buildings
Fungi in Hospitals
Allergy to Fungi
Fungi in Food
Aspergillus

Blastomycosis
Introductory Article
My Blastomycosis Story
Fatal Brain Infection
Dr G's 2 slide culture
Blastomycosis Images
Blastomycosis Medical Literature
Reflections on an Illness

More About Air and Breathing
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Stephen Gislason MD

Airborne Fungal Diseases

Molds reproduce by releasing spores into the air. The main route of entry of mold spores is through respiration of dust particles contaminated with the fungi. The ubiquitous presence of fungi in both indoor and outdoor environments is a potential health threat that is poorly understood and almost ignored in community medicine.

Many species of fungi around the home grow on food and other organic materials such as damp paper, textiles and wood.  Fungi produce allergens, enzymatic proteins, toxins and volatile organic compounds that cause respiratory disease.

Various strains of airborne molds have been implicated as the cause of asthma and hypersensitivity pneumonitis. Chronic nose and sinus inflammation have been linked to airborne fungi. Shin et al, for example, demonstrated immune responses to Alternaria by finding elevated levels of IL-5 and IL-13.

Green et al suggested that 100 genera of fungal conidia are currently recognized as sources of allergens, but the number could be greater: different components of fungal growth such as fungal hyphae and fragmented conidia are airborne and may become allergenic. Many wild species are not detected by standard culture techniques.

In addition, inhaled spores of pathogenic fungi grow in the lung and other organs, establishing chronic and sometimes lethal infections that are difficult to diagnose. There is an overlap of allergic hypersensitivity diseases with infection by a relatively few fungi that infect by spore inhalation.

Fungi produce toxins that are released into the air. Bünger et al studied five toxigenic airborne moulds of the genera Aspergillus and Penicillium collected at composting plants: sterigmatocystin, fumagillin, verruculogen, penitrem A, and roquefortine C. All five extracts caused toxic effects to cultured cells. They suggested that mycotoxins may be involved in producing the lung diseases from the inhalation of organic dust.  Panaccione and Coyle reported finding ergot alkaloids associated with Aspergillus fumigatus. Ergot molds produce an array of potent chemicals. The hallucinogen, LSD, was derived from ergot alkaloids.
See Fungi in Food

Molds Indoors

Kodama and McGee found sixteen types of indoor airborne fungi. The main species belong to the families: Aspergillus, Penicillium, Cladosporium, Mucor, Stachybotrys, Absidia, Alternaria, Fusarium and Cryptostroma. The greatest health risks are Candida, Aspergillus, Histoplasma and Penicillium.

The two most prevalent fungal infections in hospitals are caused by Candida and Aspergillus species. These organisms can occur naturally in the exterior environment and enter as spores or active fungi attached to dust particles.
More about Molds Indoors

See Fungal Infections

Rainer J; Peintner U; Pöder R. Biodiversity and concentration of airborne fungi in a hospital environment. Mycopathologia.  2001; 149(2):87-97 (ISSN: 0301-486X)

Augustowska M; Dutkiewicz J. Variability of airborne microflora in a hospital ward within a period of one year . Variability of airborne microflora in a hospital ward within a period of one year.Ann Agric Environ Med.  2006; 13(1):99-106 (ISSN: 1232-1966)

 Shelton BG; Kirkland KH; Flanders WD; Morris GK. Profiles of airborne fungi in buildings and outdoor environments in the United States. Appl Environ Microbiol.  2002; 68(4):1743-53 (ISSN: 0099-2240)

 Shin SH et al /Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi. J Allergy Clin Immunol.  2004; 114(6):1369-75 (ISSN: 0091-6749)

Bünger J et al. Cytotoxicity of occupationally and environmentally relevant mycotoxins. Toxicology.  2004; 202(3):199-211 (ISSN: 0300-483X)

 Panaccione DG; Coyle CM Abundant respirable ergot alkaloids from the common airborne fungus Aspergillus fumigatus. Appl Environ Microbiol.  2005; 71(6):3106-11

 Anthony Montanaro. The Impact of Environmental Molds in the Home 60th Annual Meeting of the American College of Allergy, Asthma and Immunology Medscape Allergy & Clinical Immunology, Nov 2002

Geiser M. et al Interaction of fungal spores with the lungs: distribution and retention of inhaled puffball (Calvatia excipuliformis) spores. J Allergy Clin Immunol.  2000; 106(1 Pt 1):92-100

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